To reduce systemic absorption of an eyedrop after instillation, what should be done?

• A. Light pressure over the lacrimal sac for 15 to 30 seconds
• B. Blink rapidly for 2 seconds
• C. Rinse with water
• D. Apply a cold compress for 5 minutes

Answer: (A)

This question tests how to minimize systemic absorption of eye drops. The best approach is nasolacrimal occlusion—gently press over the inner corner of the eye where the lacrimal sac sits for about 15–30 seconds after instilling the drop. This brief pressure blocks the tear drainage pathway into the nasal mucosa, which is a major route for systemic absorption. By slowing drainage, more of the medication stays on the ocular surface long enough to have its intended local effect, and less enters the bloodstream, reducing potential systemic side effects.

Blinking rapidly won’t prevent drainage and can just spread the drop around; rinsing with water would wash the medication away rather than keep it in the eye; a cold compress doesn’t address the drainage route and won’t reduce systemic absorption.